For example, if one of your numbers is in a cell that is located in column A and row 6, the cell reference for that number would be A6.) (A cell reference is a way to denote the location of a given cell in a spreadsheet and the combination of a cell's column number and row number. Step 1: Choose the numbers you want to subtract and make note of their respective cell references.
If you have numbers located in different cells in your spreadsheet that you want to subtract, you can do so by using cell references and a formula.
